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Dr. Glass’ Key pursuits are to comprehend transcriptional mechanisms that control the event and performance of macrophages. Macrophages Engage in important roles in immunity, wound mend, progress and tissue homeostasis. Dysregulation of macrophage functions contribute to a wide spectrum of human ailments, which include atherosclerosis, diabetes, neurodegenerative diseases, and most cancers. A serious effort on the Glass laboratory is to make use of genomics assays and related bioinformatics methods to know how macrophage gene expression systems are established And just how They can be motivated by unique tissue environments and ailment.

Final Updated: 08/04/2017 Cell colonies on agar increase in a very near linear vogue with progress charges reflective of their "Exercise". The laboratory has developed an experimental platform that will make ongoing measurements of expansion fees via time-lapse impression capture of A large number of certain genetic mutant strains, enabling us to determine the relevance of each gene during the response to stimuli for instance DNA injury through radiation or chemotherapy.

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Our All round purpose is to grasp intricate genetic variants that underlie human illness. We're notably keen on repetitive DNA variants referred to as limited tandem repeats (STRs) for a product for advanced variation.

Final Updated: 08/sixteen/2011 The laboratory, as Component of the mouse ENCODE project, is during the midst of manufacturing the very first thorough map of cis-regulatory aspects while in the mouse genome. Computational analyses are now being executed to discover the regulatory sequences controlling tissue-specific gene expression, identify the evolutionary conservation of these sequences, and predict prospective transcription aspects linked to lineage specification and animal growth.

Very last Up-to-date: 09/29/2016 Genome-vast association experiments (GWAS) have uncovered A large number of genetic loci connected to human phenotypes. Even so, typically these loci are unsuccessful to clarify the vast majority of trait heritability. Importantly, GWAS has focused mainly on very simple single nucleotide polymorphisms (SNPs), and as a consequence are prone to skip significant contributions from more elaborate forms of variants.

Previous Up-to-date: 08/04/2017 A lengthy standing question in biology is what number of (and which) genes are essential for all times. This vital core set of genes, or small genome, helps make up the mobile's “everyday living assistance process” or “chassis and energy source” on which much more intricate features and processes are developed. This list of genes is of keen fascination in the field Artificial Biology, which aims to synthesize the entire nominal genome of the organism and incorporate added functions to this genome for biotechnological, pharmaceutical and agricultural finishes.

Last Up to date: 09/26/2016 Tandem repeats (TRs) are already implicated in more than forty Mendelian conditions, including Fragile X Syndrome and Huntington's Ailment. Whilst a number of instruments can now profile quick TRs from following era sequencing data, these approaches usually do not quickly grow to for a longer period TRs that cannot be spanned by only one sequencing study.

By producing a null product based upon regional patterns of SV, we propose to establish sequences that deviate radically from expectations. Sequences that display Excessive deviation are prone to be genes which are essential for lifestyle.

Our lab develops and applies quantitative strategies to examine metabolic regulation in most cancers, stem cells, and the cardiovascular process. These knowledge-driven metabolic flux Investigation (MFA) techniques involve stable isotope tracers, mass spectrometry, and computational algorithms that examine data like a system. We use these techniques to establish metabolic dependencies in cancer cells which might be pushed by tumor genetics or even the bordering microenvironment.

Once more these projects range between entry amount (Look at benefits of two several sequence alignment techniques for subsequent Neighborhood Assessment) to Sophisticated (use non-von Neumann architectures to carry out pattern classification in true time at The complete Local community level for condition detection).

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Roles of epigenomic regulators and expression of DNA repeats in stem cells, neuronal differentiation As well as in senescence.